This hormone is produced in the pineal gland in the brain. The daily variation in light received by the eye tells the pineal gland to make bursts of melatonin. Melatonin production is suppressed by morning light that promotes alertness. The ideal light to switch off melatonin is blue light at 480 nm wavelength, but the closest light to 480 we see is the bright blue color of the sky when a sunny day.
Begin your melatonin dose at night starting at 1 mg and you can increase as tolerated. The careful it can lower your cortisol hormone and a can increase the conversion of T4 to T3 causing nightmares and the melena night with too much energy. The only time I avoid melatonin is with leukemia, lymphoma, and multiple myeloma.
Melatonin is an antioxidant at low dose, protecting DNA, RNA, and cellular membranes from oxidation. It is a pro-oxidant in cancer cells at higher doses. Obviously, cancer patients need the higher doses.
It inhibits cancer initiation and is anticarcinogenic. Melatonin directly and indirectly inhibits epidermal growth factor receptor and increases p53 expression which kills cancer. It reduces pro inflammatory cytokines which can make your cancer grow and is an aromatase inhibitor able to block estrogen which is important in estrogen driven cancers like breast cancer.
Recent studies show that increases response and survival with chemotherapy by reducing bone marrow damage and loss of platelets. He can also increase killer cells.
Because melatonin is so important, I usually use it intravenously in addition to low dose metronomic chemotherapy, repurposed cancer drugs and cancer vaccines with many other natural substances. If you are interested, please call the office at 480-361-7020.