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Lyme Disease

Lyme Disease

Lyme disease mimics over 350 different medical conditions including Alzheimer's disease, Parkinson's disease, Lou Gehrig's disease, multiple sclerosis, chronic fatigue syndrome, fibromyalgia, asthma, irritable bowel, rheumatoid arthritis, and chronic pain syndrome, ulcerative colitis, interstitial cystitis, neuropathy and many more.

When I see a patient who has multiple symptoms, I think of Lyme disease. In addition, other tick-borne pathogens such as Babesia, Bartonella, and Ehrlichia are transmitted principally through the bite of a tick. We now know that horseflies, dear flies, mosquitoes, and even spiders can carry this infection. Other modes of transmission include the placenta from the mother to the baby, breast milk, and sexual transmission.

Inflammation causes most of the symptoms

If you can lower the inflammation in the body, you can become symptom-free even if the microbes are still present. Lyme disease is due to the immune system's reaction to microbes and toxins. Most symptoms are caused by the immune system attacking the places were the microbes hideout. Additionally, there is usually the presence of heavy metals, mold infections, and other viral infections. The Lyme spirochetes invade the skin, heart, brain, blood vessels, lymphatics, muscles, tendons, joints, spleen, and every organ in the body. They can live for months to years.

Microbial biofilms

In a study published in the Frontiers in Neurology, "The emerging role of microbial biofilms in Lyme neuro-borreliosis," they state that the presence of biofilm may explain the low rate of Lyme detection and in the blood of patients that are infected and the ability of the immune system. The biofilm causes the recurrence of Lyme and the ability to tolerate multiple cycles of antibiotic treatment. This biofilm is a protective structure for Lyme. Several studies have shown the Lyme can switch from a motile to permanent status in which the are embedded in the biofilm and escape from the detention of the immune system. The biofilm needs to be broken, and specific therapies instituted to facilitate this.

These infections are persistent and need treatment. Unfortunately, the arteries in the brain can be affected as well as peripheral nerves and joints. At present, there are probably about 300 different strains of Lyme existing. We still do not know every strain. The problem is that of antibiotic resistance. Also, when you test some people for Lyme due to weak immune response, they do not test positive although they are infected, requiring new testing.

Lyme dissemination early and late disease

Early disease at 3-30 days after an infectious tick bite is the time to find it and treat it. This phase is curable if treated promptly with oral antibiotics. In the next period of 1-12 weeks after an infected tick bite, there is early dissemination. At this point, there is multi system disease and a good response seen with antibiotics. Unfortunately, in the late-stage, more than three months after the bite, there is a complex multisystem multiorgan progressive disabling disease. These are the patients I see in my office. The treatment is multimodal. The main objective is to increase the patient's immune system. Immune therapies are instituted as well as SOT.

Neurologic symptoms

These include problems with sleeping, sensory loss, loss of smell, loss of taste and hearing, visual disturbances, neuropathy, numbness, tingling, burning, crawling, and a stinging sensation. Unfortunately, there is also associated memory loss with diminished visual working verbal memory and processing speed. There is a decreased concentration of word recall and retrieval. I have seen patients confused and disoriented. Paralysis, as seen in Guillain Barre, also occurs with Lynn paralysis, foot drop and mono neuritis multiplex. I have also seen patients with Alzheimer's, Parkinson's, ALS, and multiple sclerosis test positive for Lyme disease. Infiltration into the brain is the most dangerous manifestation of Lyme disease, occurring in 10-15% of infected individuals. During the infection, the bacteria migrate through the patient altering coagulation, and immune response. The disease reaches the brain within two weeks after the tick bite. In some patients, oral antimicrobials and antibiotics are useful, but persistent forms of Lyme continue to exist in some patients despite targeted antibiotics. It's thought that these patients have a significant biofilm that needs to be broken down.

Symptoms of mast cell activation

Patients with this syndrome have intent anxiety and depression. They may experience headaches, ringing in the ears, sore throats, swollen lymph nodes, and indigestion. Unusual neurological symptoms like numbness and tingling in different body parts as well as paralysis and pseudo seizures are possible. The basic principles of treatment are to reduce the production of biochemicals coming from the mast. It is important to identify what is triggering the activation in the first place. When the triggers are eliminated, the mast cell activation disappears. In addition, there are many pharmaceutical antihistamines and effective natural products.

Chronic arthritis

These include mono, only go, or polyarticular arthritis involving the large joints, mainly in the knees, hips, or shoulders.

Hormonal dysregulation

The patients are usually fatigued and exhausted. There is a loss of libido, and the patient is very stressed and irritable. Most patients gain weight, and when I measure the hormone levels, they are low.

Neuro-mediated hypotension POTS

The patients usually have low blood pressure and symptoms of dehydration when lying down or sitting up quickly. There is autonomic neuropathy, generally with pituitary insufficiency. The patients are fatigued, and they can have rashes or palpitations and need to lay down. The blood pressure will go down upon standing and cause lightheaded and dizzy. As they stand, the heart rate goes up in compensation. There is normally associated sweating, nausea, vomiting, diarrhea and swallowing problems. I have seen patients with sleep apnea, twitching, seizures and many neurological symptoms.

Why does his chronic persistent Lyme so severe infections?

In these patients, there appears to be a high spirochete load through either multiple tick bites or a long duration that was unrecognized by them. Interestingly many people do not remember a bite or get a rash. After an extended period, there is a creation of biofilms where protected nieces are made up of mucopolysaccharides, and this is where the infection resides. Also, there are alternative forms of Lyme, such as the cyst form and the L form, which cause an additional suppression to the patient's immune system.

The problem with antibiotics

Published in antimicrobial agents and May 2015 study showed that Lyme could form drug-tolerant persister. Unfortunately, the cell survives antibiotics because they are dormant and not metabolically active. Therefore, we are now using intermittent pulsing therapy with a comprehensive natural approach of different herbs and supplements that help break down the biofilm and kill the infections. For this reason, evaluation and the treatment of the patient's immune system are exceedingly essential. Additionally, supportive oligonucleotide technique (SOT). Natural substances are also ways employed.

Aggravating factors

These include the presence of co-infections such as Bartonella, Ehrlichia, Bartonella, along with the various molds, viral infections, heavy metals, and toxins.

Treatment with natural substances versus antibiotics

Sometimes during treatment, I do use multiple antibiotics, which I try to pulse and use lower doses, but I always include natural substances. I believe the integrative approach provides the safest way to detoxify the body, kill the infections and down regulate the immune system. This approach is truly personalized medicine and requires an in-depth evaluation of each patient.

Posttreatment Lyme disease syndrome (PTLDS)

We are beginning to see patients that, after receiving appropriate antibiotics, continue to have symptoms of chronic fatigue, fibromyalgia, headache, mental confusion, and low-grade fevers. According to the New England Journal of Medicine in March 2016, approximately 20% of people who use antibiotics will have these persistent symptoms. The treatment is multimodal. They have both immunosuppression as well as an autoimmune disease.

Supportive oligonucleotide technique (SOT)

SOT therapy is a treatment that uses the messenger RNA to influence the genes in the Lyme or viral infection. The laboratory can identify specific genes in the Lyme organism or viruses and target them to damage and silence those genes effectively killing the organism. This treatment is called antisense therapy, where there is a creation of up to 1 billion copies of SOT molecules to fight the Lyme or viral infection and is called gene silencing therapy.

Combination therapy works best

Combination synergistic therapies are critical to the Lyme patient. Initially, diagnosis is made through multiple laboratories. Treatments are aimed at optimizing the patient's immune system. Treatments are tailored to each patient and based on the patient's unique genes and environmental factors. Other factors, such as viruses, mold, heavy metals, are of critical importance.

Supportive oligonucleotides (SOT) is of great value in your treatment plan.

If you would like more information on Lyme disease, please call us at 480-860-2030.

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