ALZHEIMER'S DISEASE TREATMENT
I am writing this for the over 6 million people who suffer from Alzheimer’s and the many more that suffer from age-related memory impairment. My father suffered from Alzheimer’s for many years and finally died from this devastating disease. Alzheimer’s disease is multifactorial and results from the interaction of genes and our environment.
I am now convinced that Alzheimer’s disease can be prevented and in many cases the cognitive decline can be slowed and even reversed. The anti-Alzheimer’s protocol that I have been practicing for decades if the strongest weapon that we have against mild cognitive impairment and Alzheimer’s disease. For 75 million Americans who carry the ApoE4 gene which increases the risk of Alzheimer’s dramatically, there is now hope.
Alzheimer’s disease occurs when the brain is trying to protect itself from metabolic and toxic threats. These include inflammation from infection, diet, or other causes. A decline and shortage of important nutrients, hormones, and other brain supporting molecules as well as toxic substances such as metals or biotoxins from poisons such as from mold and other infections. In order to reverse mental decline and cognitive impairment is necessary to remove the factors that are causing her brains to defend themselves by producing the protective amyloid response.
We Need to First Prevent and Reduce Inflammation and Infection.
Recent studies have shown that periodontal bacteria have been found in the blood of Alzheimer’s abrasions. The same patients have increased levels of pro-inflammatory cytokine name tumor necrosis factor which affects the permeability of the blood brain barrier allowing harmful molecules to attack brain. Periodontitis has been associated with a 6-fold increase in cognitive decline and Alzheimer’s. I also believe that mercury fillings along with root canals and poor dental hygiene are causative factors In addition the gut microbiology also plays a role and a healthy balance of good intestinal flora if absolutely essential. Infection such as Lyme disease, mold, chlamydia pneumoniae, cytomegalovirus, Helicobacter pylori, herpes simplex virus type I have all been linked to the progression of Alzheimer’s and dementia. Recent studies have now shown that the higher the infectious burden the higher the level of amyloid B in the lower the cognition.
The recent medical literature suggests that these infections need to the production of reactive antibodies, inflammation and immune complexes which further advance this vicious cycle. Other infections include salmonella, Giardia, Epstein-Barr virus, and E. coli. These all cause significant plaque formation and amyloid reduction resulting in dementia. In addition to this mold and parasites have been found to be causative factors.
Repeated Reactivation of Latent Infection is Very Dangerous
New studies have shown that by the age of 3, 100% of small children has positive for another type of latent herpes virus called HHV–6. This virus also may play a role in Alzheimer’s disease. Children age 6-16 who test positive for this infection have been shown to have lower reading and spatial reasoning scores. Both HSV 1 and cytomegalovirus infections in middle-age are associated with impaired learning and recall. The more often a person has reactivation of the sleeping viruses, the greater or his or her risk for getting Alzheimer’s dementia and also social problems and educational problems. These viral reactivation obviously depend directly on the health of our immune system. Other factors include poor diet, diabetes, chronic stress, exposure to industrial chemicals, exposure to pesticides, herbicides, and fungicides as well as excessive vaccinations.
Higher levels of cytomegalic virus are also associated with Alzheimer’s disease and cognitive decline. Interestingly another study showed a more rapid decline in mental function of Alzheimer’s patients with cytomegalic virus infection.
To prevent a reverse cognitive decline, we all need to eradicate these potential infections and optimize her immune system and reduce the chronic inflammation. In addition to this food can trigger inflammation without infection eating gluten or dairy or trans-fats can result in “leaky gut” which triggers more inflammation.
Toxic Chemicals and Alzheimer’s Disease
Toxic metals such as aluminum, mercury and lead as well as many others have been extensively studied and are shown to cause toxicity of the brain and other organs. They have been linked to Alzheimer’s. Recent evidence of shown that they cause a chemical-induced autoimmune reaction against the brain. Aluminum compounds have been added to products such as cheese, candies, coffee white nurse and even drinking water. It is also in many deodorants as well as some vaccines. The accumulation of aluminum affects memory, cognition, and activity and promotes the aggregation of amyloid the protein causing dementia and Alzheimer’s. Mercury and lead have a strong association with Alzheimer’s. Autopsy studies found increased levels of mercury in the brain tissue of Alzheimer’s disease, but not other blood urine or hair. Mercury causes increased formation of amyloid aggregates. The world is being contaminated by the burning of call in the polluted environment. I had my amalgam fillings which are 50% mercury removed. The chemicals in plastics have also shown to be detrimental to brain health. If you have had chemotherapy it can be toxic to the brain and this protocol can be extremely helpful.
Foods and Alzheimer’s Disease
Unfortunately, many of the foods we cross-react with brain protein and activate us strong immune response activating dementia and Alzheimer’s not only the typical gluten but also many other foods cross-react with her brain. Many foods have been associated with autoimmune disease and the progression of dementia and Alzheimer’s. These need to be tested for in each patient. I myself have sensitivity to gluten and for that reason after being tested my diet is quite limited. There are many foods that cause any great harm.
Hormone and Nutrient Optimization
To function best your brain needs supporting factors that include certain hormones, trophic factors and nutrients. Certain hormones such as pregnenolone, DHEA, estrogen, progesterone, melatonin, testosterone and oxytocin are important to maintain optimal brain health. These hormones canning grief brain derived neurotropic factor (BDNF) as well as exercise and a ketone plant-based diet are exceedingly important.
Mitochondrial Dysfunction and Excitotoxicity
The medical to her the energy power Plant in the cells and generate ATP which is needed for cellular function dysfunctional mitochondria are important mediators have amyloid-beta toxicity in the brain this along with free radicals and oxidative stress drive the formation of additional amyloid plaque and lead to neuronal death. Glutamate is the most abundant excitatory neurotransmitter in the brain and is necessary for normal brain function. However, too much glutamate is known as excitotoxcity. This also can be extremely detrimental to the neurons and brain cells. The glutamate is the result of overactivation of NMDA receptors leading to more neuronal loss.
Other Risk Factors
These include a history of head trauma, high homocysteine levels, silent strokes, central obesity, diabetes, high blood pressure, high cholesterol, and advancing age.
Integrative Alzheimer’s treatments
These protocols have been formulated after a complete evaluation of every person and testing is absolutely essential. Therapies are based on removing infections, eliminating inflammation, eliminating toxins as well as hormonal and nutrient supplementation as necessitated by testing. I believe that everyone should maintain optimum and brain health for years and I am an example I believe that Alzheimer’s is not inevitable, but testing is essential. I also believe that gene testing is extremely important in knowing your complete genome and how better to kill or make therapies to have the best possible outcomes. I have had several injections of stem cells and I also find them to be valuable.
Unfortunately, the prescription drugs do not work. My father was on them for years and they did nothing. Traditional medicine offers nothing in my opinion.
For many years, I have been interested in Alzheimer’s and memory loss. My father, at the age of 91, just died from a complication of Alzheimer’s. He had inherited a particular gene called the APOE-4 gene, which made him susceptible to Alzheimer’s. He was a periodontist and had been exposed to mercury his whole life.
We now know that mercury is a neurotoxin and can cause degenerative disease, especially Alzheimer’s. It seems to me that a great many things are associated with Alzheimer’s, and I have reviewed the literature extensively.
If we did not know what to do about Alzheimer’s, our best choice might be to accept and reside ourselves to a gradual deterioration of our memory.
The work of many brilliant scientists around the world had shown us that we could extend our quality of life as well as memory if we are well and willing to investing in our health. My approach to memory protection and Alzheimer’s prevention is based on peer-reviewed medical literature, all documented and researched.
We now know there is a direct correlation between exposure to heavy metals like mercury and lead and certain white metals like aluminum and Medium. There is also a relationship between exposure to pesticides, fungicides, head injury, infections, and the inherence of specific genes. If you are suffering from memory loss or have a loved one with it, these things are easily measured through blood and urine.
To understand the course of these neurodegenerative diseases like Parkinson’s, Alzheimer’s, and others, it is important to understand the brain’s unique immune system, which is controlled by microglia and astrocytes.
Some new research suggests it is a autoimmune disease.
Normally, these brain immune cells are quiet in a resting state, but when they are activated by excitotoxins, viruses, bacteria, fungus, or metals, they begin to attack the brain.
The brain’s immune system is activated and cannot shut off. It continues to release destructive cytokines and free radicals that can continue for decades. The vital importance of brain energy is to process of energy generation in mitochondria.
The mitochondria are also the source of free radicals and energy production in our bodies. Interestingly, studies have shown that an average male age 55, having the APOE-4 gene, was found to have significant suppression of the mitochondrial energy production in the same areas of the brain of affected and Alzheimer’s dementia.
This was decades before the onset of disease.
Even more startling, they found that men that were carriers of this APOE-4 at an average age of 30 years found that even at this young age, their brain mitochondrial production was significantly impaired in the same regions.
So the question is, “What is causing our mitochondria to fail, which causes our memory to fade?”
We now live in a sea of toxic chemicals in our environment – in our drinking water, the air we breathe, and the fluid we eat.
Compelling evidence indicates that many of these chemicals impair the mitochondria to make energy. Mercury, lead, cadmium, and aluminum are toxic to the mitochondria. These result in activation of the microglia leading to Alzheimer’s and memory loss. It is also shown that inflammation is triggered by vaccinations that can increase the neurotoxicity of a number of these environmental toxins, especially pesticides.
What Is Your Brain State?
In our 50s or sooner, we all experience those “senior moments” when we forget a familiar name, find ourselves word-searching in mid-sentence, or misplaced items. For most of us, this is due to normal age-related memory impairment or simple distraction.
For too many, however, these are absences that can represent the tip of the iceberg, a condition called mild cognitive impairment (MCI). MCI is very different from normal memory loss because it results from the same pathologic process as Alzheimer’s. This is the accumulation of beta-amyloid plaque in the brain. MCI is considered Alzheimer’s, and 10% of people with MCI will progress on to Alzheimer’s.
When I see a patient for the first time, I perform professional cognitive testing to evaluate the state of the brain’s health.
There is also a new test called the Amyvid PET scan, which is the first imaging study that can measure the amount of beta-amyloid plaque in the brain.
Beta-amyloid plaques accumulate even before cognition declines, so the Amyvid scan alerts us to the presence of impending Alzheimer’s. At this stage, we have the best chance to arrest it or slow its process. Whichever category you fall into, normal mild cognitive impairment, or Alzheimer’s, this program is designed to help you. In addition to the Amyvid scan, there are also SPECT brain scans which I obtain.
Why treatment of memory loss and Alzheimer’s works
My approach empowers you to take control and become your healer. I feel most doctors believe there is no cure because we do not yet have a magic bullet in the form of a single drug to stop or reverse the brain deterioration.
The reason is that drug treatment can target only a single chemical reaction in the body, but Alzheimer’s is a different animal; its causes are many, so unlike treating strep throat, targeting one single chemical reaction will not work.
For the most part, the FDA approved medications for Alzheimer’s disease merely increase the production of a neurotransmitter, acetylcholine in the brain, for temporary improvement of cognition, BUT the underlying disease process continues. The only exception is the drug Memantine, which works by a different mechanism and whose effect is only temporary.
The key to controlling this disease is examining all the biochemistry we know and taking a multifaceted approach to alter the biochemistry.
The biochemistry of Alzheimer’s is now significantly understood. The problem is, no one has attempted to simultaneously influence all the pathways by which Alzheimer’s develops, and clean up the mess until now. If you are on a prescription drug for Alzheimer’s, you should know that my program will not interfere with your medication and that you may continue to stay on it.
More than 35-million people have dementia today. Each year, 250,000 new cases are documented within the United States, and 4.6-million new cases occur worldwide, or one new case every 7-seconds. By the year 2030, there will be 70-million people affected. Alzheimer’s disease is the most common form of dementia. As many as half the population at age 85 has Alzheimer’s, and 1 in 8 over the age of 65. Half of the elderly in long-term care facilities are suffering from Alzheimer’s.
Stages of Alzheimer’s
Stages of Alzheimer’s go from stage I to stage 7, stage 1 representing no impairment, and stage 7 representing very severe decline.
Alzheimer’s usually surfaces after the age of 60 with a marked decline of cognitive function such as remembering, reasoning, and planning.
There is also a gradual decline in mental function, beginning with daily noticeable lapses in memory, followed by losses and inability to plan and execute tasks, and having good judgment. Eventually, memory loss increases in severity. There is inability to articulate words, and changes in mood and personality. There is confusion, feeling withdrawal, disorientation and even hallucination.
People with Alzheimer’s live an average of eight years from its diagnosis, but their interval can be as short as 1 or as long as 20. Remember, Alzheimer’s disease does not appear suddenly. It is progressive and begins decades before the first symptoms. In 10% of cases, it occurs in people in their 40s and 50s. This is so-called early-onset of Alzheimer’s.
The incidence of Alzheimer’s is growing rapidly. Alzheimer’s disease is not a normal process of aging, it is an abnormal condition. In fact, the age at which people are getting Alzheimer’s is growing younger over time.
The best time to find Alzheimer’s is before it progresses to the point that symptoms become easily recognizable. I perform not only scanning, but also do the mini mental state examination (MMSE) to screen for dementia. Other reasons of dementia, including vascular dementia and Parkinson’s disease and multiple sclerosis are also ruled out.
Why Do We Get Alzheimer’s?
A number of processes are believed to contribute to the cognitive decline seen in Alzheimer’s. There are several factors along with an increased propensity with abnormal genes to develop memory loss in Alzheimer’s.
Free Radicals Oxidative Stress:
Oxidative stress is a process in which highly reactive molecules called free radicals damage cell structure. Free radicals are bi-products of normal metabolism, but during states of the brain toxicity and metacognitive dysfunction, we generate more free radicals. Oxidative stress both facilitates some of the damage caused by amyloid plaque and also increases its formation. My first approach in treatment of memory loss in Alzheimer’s is to find why the patient is making excess free radicals, and to limit them through supplementation.
A prominent finding in Alzheimer’s disease is senile plaques. These are clumps of protein called amyloid beta protein. They accumulate especially in the hippocampus, which is involved in memory consolidation. Aggregates of amyloid plaque have been shown to contribute to oxidative damage, excitotoxicity, inflammation cell death, and formation of neurofibrillary tangles.
Tangles are made up of microtubules with specialized proteins called tau proteins. In Alzheimer’s, these microtubules disintegrate and the tau proteins clump together to form aggregates of neurofibrillary tangles. These, along with beta amyloid, initiate several processes leading to cell death.
Source of Free Radicals:
Diet is a major source of free radicals. That is why we need to eat a nutrient-dense low-carbohydrate organic diet. Certain food additives, pesticide residue, chemicals and pollution increase our free radical load. Be aware that polyunsaturated oils are so prone to free radical formation that the body’s antioxidant reserves are quickly eaten up to neutralize them.
When proteins and sugars are cooked together at high temperature in the absence of water, advanced glycation end-products (AGE) are formed. You can tell when AGEs perform by the color of the cooked food. It turns brown. This browning effect imparts a tasty flavor. The “golden brown”is the result of AGEs. This browned coloration of cookies, bread crusts, roasted and barbecued meats is not good for our brains.
Studies have shown that AGEs are associated with Alzheimer’s as well as diabetes. Most of the AGEs in our body is from eating sugar, and refined carbohydrates, fructose. Fructose greatly damages cell membranes, because it cause AGE degeneration and makes insulin resistance worse. It does not matter if the fructose is from high-fructose corn syrup or Agave syrup.
Combating glycation is an important step in arresting and reversing Alzheimer’s. Glycolated proteins are higher in Alzheimer’s brains, and are also found in the plaques and tangles. Glycation occurs at the high-known level in diabetes, and diabetics have increased risk of Alzheimer’s. Excessive glycation also promotes more oxidative stress.
The inflammatory process appears to play a role in development of Alzheimer’s. When high levels of amyloid plaque accumulate in the brain, it activates the body’s immune system resulting in more inflammation.
Part of the inflammatory response to beta amyloid appears to be facilitated by tumor necrosis factor – alpha (TNF-alpha). TNF-alpha is a pro-inflammatory cytokine that is often found in high levels in the serum and cerebrospinal fluid of Alzheimer’s patients.
I feel that it represents a potential target for Alzheimer’s therapy. The inflammation is caused by all the known toxins such as metals, infections such as Lyme, labial herpes, Chlamydia, and others. For this reason, occult infections are looked for in my patients.
In the American Academy of Neurology there was an article where workers exposed to lead, such as smelters or factory workers, had double the risk of developing Alzheimer’s. It has long been known that children exposed to lead can develop brain damage. Low-level to lead in children is characterized by low IQ. Lead exposure is also associated with ALS, Parkinson’s disease, as well as Alzheimer’s.
Aluminum has long-known to be toxic to living tissue. It causes changes in nerve tissue similar to that seen in the brains of Alzheimer’s disease. There is now a statistically significant positive relationship between Alzheimer’s and aluminum. Aluminum is found in processed cheese, baking powder, table salt, and antacids such as DiGel, Maalox, Gelusil, Mylanta, buffered aspirin, antiperspirants and deodorants, as well as in aluminum pots and pans. Aluminum cans can also transfer a significant amount of aluminum to beverages. Vaccines often contain aluminum as well as mercury.
Excess iron can also lead to Alzheimer’s and other degenerative diseases. Iron-induced free radical reactions have been shown to damage arteries and increase the risk of Alzheimer’s, causing destructive free radicals that contribute to the amyloid beta deposition and neurofibrillary tangles. One of the highest dietary sources of iron is white flour. Almost all white flour has been enriched with flour in the form of ferrous sulfate, so before you eat any of these products, please think about it. Almost all hot and cold cereals are fortified with additional iron; this includes some breakfast cereals, such as Total and Product 19.
Mercury is the most toxic non-radioactive metal known. Just inhaling the vapor can cause brain damage. Animal studies showed that mercury causes changes in the brain that are identical to that in Alzheimer’s.
I suggest you go to the University of Calgary’s web site and search “effect of mercury on the brain cells”. Chronic low-level exposure causes tremors, impair cognitive ability, memory disturbance, depression, and personality changes.
Be careful with fishes that have high mercury levels such as Tuna, Grouper, Chilean Sea Bass, and Mackerel. Avoid Tile Fish, Orange Roughy, and Marlin. Fish with the lowest include Salmon, White Fish, Sardines, Shrimp, Tilapia and many others. The other major source of mercury in this century is amalgam dental fillings.
Animal studies show that exposure to mercury vapor in concentrations known to be released by dental amalgams in people produce brain lesions identical to that seen in Alzheimer’s. Mercury erodes the myelin covering around nerves, also suggesting a link to multiple sclerosis. In the warm and acidic environment of the mouth, mercury vapor is released at much higher rates. When food is consumed, abrasions to fillings by chewing along with exposure to hotness of the foods, accelerates mercury vapor. Small doses of mercury tend to collect in the brain tissue.
It was also noted that the amount of mercury found in a baby’s hair is proportional to the number of fillings in the mother’s teeth. I feel that all mercury fillings should be replaced, as mine were replaced, and appropriate mercury testings performed.
You need to protect yourself against the damage that mercury does in your tissues and brain, and remove as much as possible. It is a difficult and slow process.
It has long been known that infections are associated with Alzheimer’s as well as Parkinson’s disease.
We now know that patients with Alzheimer’s have been found to have increased number of spirochetes such as Lyme (Borrelia) and co-infections.
There is also increase in herpes virus (HSV-1), Chlamydia pneumonia, Epstein-Barre virus, human immunodeficiency virus (HIV), picornavirus, Borna disease virus, Helicobacter pylori, and Cytomegalovirus.
These viruses have now been shown to set up a chronic autoimmune response with chronic inflammation and chronic free radicals. There is a persistent low-grade infection that can persist indefinitely.
Of interest, when the body is infected with these organisms, the body responds by producing amyloid plaque in its defense. Amyloid plaque is not just restricted to infection; it is also produced in response to traumatic brain injury, stroke, and chemical toxins.
We now know that people suffering from systemic infections have an overactive immune system, and I perform a tumor necrosis factor – alpha test if I suspect inflammation.
We now know that TNF-alpha crosses the blood-brain barrier and stimulates microglia, triggering inflammatory response in the brain.
Neuro inflammation triggered by systemic infection or trauma can cause a rapid decline in cognition and motor function.
Recent studies suggest this is a autoimmune disease. I do extensive testing for this.
The Dental Connection: Oral Health in the Brain:
The health of our teeth and gums has long been known to affect the health of the rest of our body. The most common organisms associated with Alzheimer’s are also associated with poor oral hygiene. Poor oral health has been linked to a number of heath problems, of which Alzheimer’s has now been added to the list.
The mouth is a breeding ground of 600 species of bacteria alone, and other viruses and spirochetes. Periodontal or gum disease starts with plaque, and an overgrowth of these can become problematic in many patients.
Several species of oral spirochetes known to cause periodontal disease area also seen in the DISEASE.
ROOT CANALS, AN OUNCE OF PREVENTION
For those of you who want to save yourselves from ever encountering or experiencing an affliction such as Alzheimer’s or Parkinson’s disease, we like that these diseases take decades to develop. In the case of Alzheimer’s disease, approximately 70% of the brain cells responsible for memory are destroyed before symptoms become noticeable.
Once symptoms surface, the brain is already in an advanced stage of degeneration. You do not want to wait until most of your brain is dead before you start to do about it. The old saying “An ounce of prevention with worth a pound of cure” is definitely true when it comes to Alzheimer’s. You can stop Alzheimer’s and Parkinson’s before they take over your life, but you must start now.
Keeping what you have now is far easier than trying to recapture what has been lost. From the preceding literature, you now realize that Alzheimer’s and all neurodegenerative disease such as Parkinson’s and multiple sclerosis is multifactorial and multifaceted.
The amyloid beta plaques as well as neurofibrillary tangles are a consequence of the inflammation as well as oxidative stress seen with free radicals. There is excitotoxicity secondary to glutamate and over-activation of the N-methyl-D-aspartate (NMDA receptors) and modulation of this receptor is a way to lessen some of the damaging effects of excess glutamate signaling.
The FDA has approved Memantine (Namenda) for the treatment of mild to moderate-severe Alzheimer’s.
There is also a noted correlation between infections as well as low levels of certain sex hormones namely: Testosterone, estrogen, progesterone, DHEA and pregnenolone.
My program is multifaceted, and is aimed towards decreasing amyloid plaque formation as well as limiting inflammation, free radicals, infection, mitochondrial dysfunction, and hormone imbalances.
I have been involved with Alzheimer’s research for many years.
My father just died at 91 with Alzheimer’s. I think that there is much to do in prevention and slowing the progress of the disease. You can see that it is multifactorial, and one prescription drug will not cure this nor prevent this.
I think that rebuilding the brain with essential micronutrients as well as killing infections, eliminating heavy metals, and improving oral hygiene is paramount. New brain cells can be grown, and SPECT brain scanning can show dramatic increases in brain viability after treatment.
I DO TESTING OF YOUR MITOCHONDRIA, HEAVY METALS, INFECTIONS, FREE RADICALS, AUTOIMMUNITY
I use HYPERBARIC OXYGEN, PHOTON THERAPY WITH THE LIGHT BEAM GENERATOR, MICROCURRENT, PEMF( HIGH GAUSS MAGNET) , IV THERAPY, IV OZONE , CHELATION AND OTHER TREATMENTS.
Conventional Alzheimer’s treatment relies heavily on pharmacologic modulation and raising acetylcholine levels in the brain. There may be small symptomatic improvement initially, although the underlying process of the disease is unaffected.
The acetylcholinesterase inhibitors are typically the first line of drugs for mild to moderate. The drugs currently used are Aricept, Exelon, Razadyne (which is galantamine), and is also an over-the-counter nutritional. Although studies have repeatedly found that these acetylcholinesterase inhibitors reduce Alzheimer’s symptoms at first, they do not halt or reverse the underlying disease. The next group are the NMDA receptor blockers, which is Namenda, an N-methyl-D-aspartate receptor antagonist.
How do therapies treat the underlying disease:
The homework abnormality in Alzheimer’s is the accumulation of beta amyloid plaque and neurofibrillary tangles in the brain. In healthy brains, a significant amount of plaque does not occur. This plaque is formed from a specific protein called amyloid precursor protein (APP). But, the protein does not do the manufacturing on its own.
It relies on the action of two main enzymes: One is called beta secretase, and the other is gamma secretase.
There is also an alpha secretase, which make an alpha amyloid protein, which is turned into excitable, harmless proteins, which do not change normal brain function.
My goal is to stimulate the good enzymes that turn APP into harmless protein and inhibit the beta amyloid protein. It is also now known, that in an Alzheimer’s brain there are also neurofibrillary tangles.
In Alzheimer’s brain, the tau protein undergoes excessive phosphorylation, resulting in structural changes called cross-linking in tangles. The brain cell loses its structural integrity, almost like a building collapsing. There are many nutraceuticals that can influence Alzheimer’s in several ways.
We can effect less beta amyloid production as well as increase the clearing of the beta amyloid plaque and produce ewer neurofibrillary tangles.
Remember, the plaquing tangles cause trouble and are toxic to brain cells, literally killing them. Protecting our brain from plaque and tangles is accomplished first by reducing oxidation (free radicals) and glycation.
This in turn will reduce inflammation, improve insulin sensitivity, and improve energy production in the mitochondria.
There are no fewer than 7 double-blind placebo-controlled clinical trials in Alzheimer’s patients which show that this supplement slows the decline on cognitive testing. There is also recent studies showing that it inhibits Alzheimer’s by reducing oxidative damage and production of beta amyloid plaque and the cleavage of pro-proteins, resulting in apoptosis, or cell death of abnormal cells.
Alpha-lipoic Acid (LA):
Alpha-lipoic acid has been shown to improve cognitive function in groups of Alzheimer’s patients. Unfortunately, no significant trials followed because this is not patentable by the drug companies. Research does show that lipoic acid inhibits oxidation and the cellular toxicity of beta amyloids. It also increases glutathione, mitochondrial energy production, and increases mitochondrial number as well as increasing insulin sensitivity. It has consistently demonstrated the ability to dramatically slow progression of dementia.
Vitamins D3, B6, B12:
The benefits of certain B vitamins in the brain are several, but the most important is the control of homocystine. It is a toxic amino acid, and levels are easily measurable in the bloodstream. There is increased risk of Alzheimer’s, which is increased by 50% by every 5-unit rise in homocystine levels. A recent study showed that a level above 14 has an associated double-risk of Alzheimer’s. Homocystine is removed by the body by a process called methylation, and is important to be removed. I keep homocystine to the lower ends of normal range.
In an article published in July 2011 in Alzheimer’s and Dementia there was a clear association between homocystine and Alzheimer’s.
Vitamin D3 works through a multitude of pathways and has been shown to decrease amyloid plaque as well as increase nerve growth factor and lower inflammation. Alzheimer’s patients have lower vitamin D levels than people without the disease.
Caffeine reduces the beta amyloid production, it appears to inhibit pathways that leads to tall fractionation, and exert an anti-inflammatory and antioxidant activity on the brain. Several studies have shown that a middle-aged person who trying 3 to 5 cups of coffee totaling about 300-500-mg of caffeine per day and had a 65% lower risk of developing Alzheimer’s later in life then those who did not drink coffee. My second given caffeine demonstrated significantly less beta amyloidotic in the hippocampus, the brain area related to memory.
Apparently, caffeine and habits beta amyloid plaque by inhibiting the activity of the activity of the harmful enzymes, beta and gamma secretase.
Curcumin binds copper and iron to prevent the oxidative and beta amyloid-producing effects of these metals, and it also appears to interfere with the formation of amyloid plaques once beta amyloid has been created. Other studies had shown that with curcumin there was increase in clearing of the beta amyloid plaque. It stimulates BDNF TO GROW NEW STEM CELLS.
GPC (glycerylphosphorylcholine, phosphatidylcholine, and glutathione):
These drugs not only our a powerful antioxidants, but they can also increase acetylcholine levels. There are many articles in GPC showing how it can significantly benefit dementia patient’s, some of them double-blind proceed vocal controls.
MEDIUM-CHAIN TRIGLYCERIDES (MCT):
MCT is found in coconut oil and appears to be useful in appears to be useful in improving cognition in Alzheimer’s. In fact, there is now a prescription version called Axona, which is now available, but in my opinion, these are over-priced and totally unnecessary.
Coconut oil and MCT oil are widely available over-the-counter, and did not need a prescription. The benefits of MCT appears to be the ability of these fats to produce elevation of ketones bodies in the bladder and brain, and these ketones act as an alternative two glucose for fueling brain cells.
Brain imaging and basic science studies revealed a glucose metabolism is impaired and Alzheimer’s patient’s, and some referred to it as the third diabetes. These ketones provide an effective fuel for the brain. Ketones have been shown to block the detrimental effects of low oxygen and improving oxygen delivery to the brain.
Ketones increase blood flow to the brain by 39%. Multiple studies have shown that ketones protect the brain from damage caused by interruption of oxygen delivery to the brain. In tissue cultures, ketones have been shown to increase survival in motor neurons.
Ketones significantly reduced the amount of amyloid plaques that develops in mouths in dog models in Alzheimer’s.
The ketones improved daytime activity, increased performance of visual-spatial memory tests, and increased learning. Ketones improve the activity of neurotrophic factors, small proteins that nourish the neurons and let them make neurotransmitters and other chemical signals. The ketones also supply the lipid-building blocks for neurons and essentially new cells. They are a high-energy source that can be used by every organ in the body except the liver.
They protect the brain, reduce formation of free radicals, protect against chemical toxins, and protect against seizure disorders and epilepsy. They have also been found to reduce the liver’s output of glucose, and lower blood sugars in diabetics, as well as protecting against cancer, and improve heart function. Medium-chain triglycerides in coconut oil are an important part of my protocol.
N-acetylcysteine, Omega-3 fatty acids with DHA, phosphatidylserine, glutathione, resveratrol, vitamin C, vitamin E, and beta carotene all have studies showing improvement in memory loss.
Additionally, carnosine and PQQ can regenerate mitochondria as well as improve the outcome of Alzheimer’s. Protein-rich polypeptides (PRP) were also used for amyloid plaque prevention as well as Huperzine A and Bacopa.
There are many other nutraceuticals that are used in my office to improve the outcomes of Alzheimer’s. Anyone reading this with memory loss or Alzheimer’s who is not suffering from known heart disease, in my opinion should stop their ‘statins.
Please refer to other areas of this site concerning ‘statins.
The angiotensin-converting ACE inhibitors as well as angiotensin-receptor blockers are frequently used in the treatment of high blood pressure. Some of the older drugs do not cross the blood-brain barrier. In one study, researchers found that for every year that a person takes essentially active drugs, the rate of cognition decline was reduced by 65%.
In contrast, the incidence of dementia was increased to 20% in those taking the ones that did not enter the brain.
A recent study in 2010, published in the British Medical Journal demonstrated that was taking the angiotensin-receptor blockers had a 19% lower rate of Alzheimer’s than those taking the older ACE inhibitors. I, myself, and taking and ARB that crosses the blood-brain barrier, and I make similar recommendations for my patients.
For those without high blood pressure, but at increased risk of dementia or Alzheimer’s, he may discuss with your doctor using a low-dose ARB in hopes of preventing further damage.
Proline-Rich Polypeptides: PRP Complex
Prolene-rich polypeptide complexes, highly stabilized, have been isolated from colostrum. They appear to be highly effective, and in vitro demonstrates they may offer neuro-protection including anti-inflammatory and antioxidant activity, and support mitochondrial function.
In a series of experiments, researchers found that RPR completely abolished amyloid plaque formation, and in a longer study, it was shown that the friables were much shorter and less dense.
There was also noted to be a down-regulation in inflammatory pathways such as the interleukin 1 and tumor necrosis family, and down-regulation in expression associated with amyloid plaque formation.
How Hormones Affect Alzheimer’s:
Is it a coincidence that hormone levels decline with age, or is that alzheimer’s disease increases without age? I think not. As our bodies age from oxidative stress, glycation, inflammation, sleep deprivation, chronic stress, and lifestyle errors, our endocrine glands age too.
Hormones began to decline in his early is age 30. For example, around that age testosterone levels beginning to decline by an average of 1% per year. DHEA drops twice as fast, by 2% per year. Melatonin drops by about 80%, sometime between its peak at age 13 and age 35. Estradiol and progesterone undergo a gradual decline in women.
Hormones are essential for brain health.
Testosterone benefits memory loss in Alzheimer’s in several ways. It reduces beta amyloid production, enhances beta amyloid breakdown and removal, protects brain from beta amyloid already there, and reduces the cleavage of tau to prevent neurofibrillary tangles.
In population studies of normal men, those with higher testosterone levels were shown to have better cognitive functions than those with lower levels.
Testosterone replacement in normal-aged men experience improvement in both verbal and spatial memory. These studies showed benefit when the testosterone was replaced to the upper limits of normal.
Testosterone influences brain level to beta amyloid through two other hormones:
Dihydrotesterone, and estradiol.
These two hormones stimulate activity of an enzyme called neprilysin, which cleaves beta amyloid into smaller and more soluble components that can be removed by the brain.
Testosterone has been shown to increase the production of alpha amyloid at the expense of beta amyloid production.
To put it simply, testosterone reduces the production of beta amyloid plaque in the brain.
Testosterone also blocks calpain, inhibiting neurofibrillary tangles formation. This reduction in tangles by testosterone was further confirmed to improve brain cell survival. Finally, testosterone has been shown to protect brain cells from the toxicity of beta amyloid by increasing the production of brain-protective protein called HS protein 70.
Estradiol in addition to testosterone, increases the production of alpha amyloid, reducing beta amyloid production. It also increases, like DHT neprilysin, helping break down and remove beta amyloids in the brain.
Estradiol also increases insulin-degrading enzyme, (IDE) and transthyretin, and like testosterone, estradiol boosts production of HSP70, protecting brain cells from amyloid plaque already there.
Of interest to note is postmenopausal women with Alzheimer’s had lower levels of estradiol in the spinal fluid than women without Alzheimer’s, and cognitive tests were higher in women with higher estradiol levels, and women with Alzheimer’s improved when treated with bio-identical estrogen.
When progesterone was administered, it also was shown to slow the production of beta amyloid plaque.
There was an increase in brain levels of BDNF, the important protein that stimulates development of new brain cells, and helps establish connection between brain cells. There was also slowing of the degeneration of tau protein, which begins to process the development of neurofibrillary tangles. Progesterone augments testosterone and estrogen use.
Even though progesterone is a female hormone, I, myself, as well as my male patients, use progesterone to slow the Alzheimer’s process, and for prostate and heart protection.
The benefits of DHEA are many. There is a direct inhibition of the activity of beta secretase, inhibiting beta amyloid formation.
Studies have shown that Alzheimer’s victims have lower DHEA-S levels than matched controls, in the volume of their hippocampus, the memory area of the brain.
The brain shrinks as DHEA-S levels decline. Incubating brain cells with DHEA also lowered interleukin 2, which accelerates the Alzheimer’s process.
A study performed in 2010 on adult mice showed that beta amyloid protein works against the survival of new brain cells that were forming, but that with treatment with DHEA aided both the survival and growth of young brain cells. One of the ways beta amyloid protein kills brain is by opening up calcium channels, and the calcium kills the cell. DHEA has been shown to decrease the calcium influx into the cells by beta amyloid.
A protein called VEGF promotes the delivery of new blood vessels into the brain, and this was increased by DHEA. Other levels showed that low DHEA l
evels correlated with higher phos relation of tau proteins and beta amyloid relation.
Melatonin has been shown to prevent cell damage induced by beta amyloid in the hippocampus of the brain. This is the primary memory region. Melatonin was shown to greatly reduce oxidation in the brain and improve mitochondrial function.
DHA, NOT EPA, IS ALSO CRITICAL TO BRAIN FUNCTION AS IS PHOSPHYTIDYL CHOLINE WHICH WE DO IV. OTHER HORMONES SUCH AS THYROID AND GROWTH HORMONE ARE DISCUSSED ELSEWHERE ON THIS SITE TREATMENTS INCLUDE IV THERAPY, IV OZONE, IV CURCUMIN, HYPERBARIC OXYGEN , MICROCURRENT, PEMF HIGH GAUSS MAGNET THERAPY PEMF , PHOTON AND THERAPY WITH THE LIGHT BEAM GENERATOR
The treatment of Alzheimer’s is multifaceted and is involved with decreasing free radicals, glycation, inflammation, as well as decreasing the production of beta-amyloid and increasing elimination.
The abnormal tau protein is also stabilized, and immunotoxicity as well as hormone imbalance, infections, dental health, and heavy metals or pesticides is evaluated.
I believe that all children involved with combat sports should probably have a gene test to make sure they do not carry an increased susceptibility to mild cognitive impairment or Alzheimer’s at a later stage of their life.
Evaluation using professional cognitive testing along with SPECT brain scans and Amyvid PET scan is done along with a comprehensive battery of blood and urine tests.
These testings look at heavy metals, infections, gastrointestinal health, and neurotransmitter balance, autoimmune dysfunction, mitochondrial analysis, amino acids, fatty acids, minerals, free radicals, toxins, heavy metals, cytokine evaluation, and gene testing.
Please keep in mind that Alzheimer’s and dementia is not part of the normal aging process.
- If you have herpes sores on your mouth, Chlamydia, HIV, Lyme or poor dental health, you are at risk.
- If you have amalgam fillings or work with heavy metals, you are at risk.
- If you have poor dental health with root canals, you are at risk.
- If you are surrounded by electromagnetic radiation, you are at risk.
After evaluating your brain state, recommendations will be made concerning infection control, oral health, heavy metal toxicity, gut health, food allergies, inflammation, thick blood, and hormonal imbalances.
The progression of Alzheimer’s is not inevitable.
I also use other prescription drugs such as piracetam and many other modalities, such as hyperbaric oxygen and trans-magnetic stimulation using a pulsed-electromagnetic-frequency magnet (PEMF), photon therapy with the light beam generator and microcurrent therapy. After extensive blood and urine testing, a personalized program based on your needs is developed.
HOW DO WE TREAT ALZHEIMER'S DISEASE?
The treatment of Alzheimer’s is multifaceted and is involved with decreasing free radicals, glycation, inflammation, as well as decreasing the production of beta-amyloid and increasing elimination. The main treatment protocol consists of IV therapy, IV ozone, and IV chelation to detoxify. In addition to various IV's, we use other prescription drugs such as piracetam and many other modalities, such as hyperbaric oxygen and trans-magnetic stimulation using a pulsed-electromagnetic-frequency magnet (PEMF), photon therapy with the light beam generator and microcurrent therapy.
WHAT OUR PATIENTS ARE SAYING
The Silver Cancer Institute has had the pleasure of helping countless patients on their road to recovery. Dr. Silver has treated patients from all backgrounds and walks of life, and we've seen even the most dire cases reach and stay in remission with our treatments. Here are a few of the inspirational testimonials and survivor stories we've witnessed at the Silver Cancer Institute, told by the patients themselves.